| Identification | Back Directory | [Name]
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride | [CAS]
2250025-93-3 | [Synonyms]
Clozapine N-oxide dihydrochloride
Clozapine N-oxide dihydrochloride salt
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride | [Molecular Formula]
C18H21Cl3N4O- | [MDL Number]
MFCD31544504 | [MOL File]
2250025-93-3.mol | [Molecular Weight]
415.745 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at 4°C,stored under nitrogen | [solubility ]
Soluble in DMSO | [form ]
A crystalline solid | [color ]
Orange | [Water Solubility ]
Soluble in water (100 mM). Always store solutions at -20°C. |
| Hazard Information | Back Directory | [Biological Activity]
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and an agonist of human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di. | [in vitro]
Clozapine N-oxide (CNO) can bind to non-DREADD receptors at concentrations required for DREADD activation, and undergoes reverse-metabolism to its parent compound clozapine, an atypical antipsychotic that acts at a variety of pharmacological targets and produces numerous physiological and behavioral effects. | [target]
Human muscarinic designer receptors (DREADDs) | [storage]
Store at 4°C,stored under nitrogen |
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