| Identification | Back Directory | [Name]
1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1) | [CAS]
2253744-57-7 | [Synonyms]
1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1) | [Molecular Formula]
C20H21Cl3N8O3 | [MOL File]
2253744-57-7.mol | [Molecular Weight]
527.79 |
| Hazard Information | Back Directory | [Description]
TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. | [storage]
Desiccate at RT |
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