| Identification | Back Directory | [Name]
Fmoc-GGFG-Glycolic acid | [CAS]
2264011-98-3 | [Synonyms]
Fmoc-GGFG-Glycolic acid
(S)-11-benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid | [Molecular Formula]
C33H35N5O9 | [MOL File]
2264011-98-3.mol | [Molecular Weight]
645.67 |
| Chemical Properties | Back Directory | [Boiling point ]
1107.2±65.0 °C(Predicted) | [density ]
1.339±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.20±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Preparation]
benzyl(S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid (150 mg，0.2 mmol), methanol (8mL), and DMF (1mL) were added to the single-mouth bottle, and then Pd/C (45mg, 5%) was added for hydrogenation reaction for 2 hours. After filtration, 1.8 mL of diethylamine was added to the filtrate, and the mixture was stirred at room temperature for 2 hours. The crude product is obtained by reducing pressure concentration. Finally, (S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid was obtained after purification.
 | [Uses]
Fmoc-GGFG-Glycolic acid ((S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid) is a cleavable ADC linker with an Fmoc group and a terminal carboxylic acid group. |
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Abydos Scientific
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