| Identification | Back Directory | [Name]
(1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate | [CAS]
2265886-81-3 | [Synonyms]
(1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate | [Molecular Formula]
C59H73N5O14 | [MOL File]
2265886-81-3.mol | [Molecular Weight]
1076.25 |
| Chemical Properties | Back Directory | [Boiling point ]
1157.8±65.0 °C(Predicted) | [density ]
1.250±0.06 g/cm3(Predicted) | [solubility ]
DMSO:107.62(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
Solid | [pka]
10.81±0.40(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Description]
dTAG-47 is a degrader targeting mutant FKBP12F36V fusion proteins. It comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-47 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo. dTAG-47 is generalizable to a range of fusion proteins. It is useful as an alternative to genetic methods for target validation. | [storage]
Store at -20°C |
|
| Company Name: |
ChemShuttle, Inc.
|
| Tel: |
0510-83588313-802 18800520310; |
| Website: |
https://www.jiehuapharma.com/ |
|