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ChemicalBook--->CAS DataBase List--->2267306-14-7

2267306-14-7

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2267306-14-7 Structure

2267306-14-7 Structure
IdentificationBack Directory
[Name]

Pomalidomide-PEG2-N3
[CAS]

2267306-14-7
[Synonyms]

Pomalidomide-PEG2-N3
Pomalidomide-NH-CO-PEG2-N3
[Molecular Formula]

C19H20N6O7
[MDL Number]

MFCD32198604
[MOL File]

2267306-14-7.mol
[Molecular Weight]

444.4
Chemical PropertiesBack Directory
[Melting point ]

188 °C
[storage temp. ]

2-8°C
[solubility ]

DMSO: 90 mg/mL (202.52 mM)
[form ]

Solid
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

Protein degrader builiding block Pomalidomide-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
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