| Identification | Back Directory | [Name]
N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA | [CAS]
228544-65-8 | [Synonyms]
VULM 1457
N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA | [Molecular Formula]
C25H27N3O3S | [MDL Number]
MFCD10687104 | [MOL File]
228544-65-8.mol | [Molecular Weight]
449.57 |
| Chemical Properties | Back Directory | [Boiling point ]
535.0±50.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble to 100 mM in DMSO | [form ]
Powder | [pka]
13.79±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
VULM 1457 is a cholesterol acyltransferase inhibitor. | [Biological Activity]
Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolaemic rats. | [in vivo]
VULM 1457 significantly reduces atherogenic activity in animal experimental atherosclerosis[1].
VULM 1457 protect the hearts of diabetic–hypercholesterolaemic rats against ischaemia/reperfusion injury in vivo[2].
VULM 1457 (50 mg/kg/day; administered as an admixture to the fat-cholesterol diet for 5 days) significantly decreases plasma total cholesterol levels (1.7±0.1 mM vs. 2.9±0.5 mM in diabetic–hypercholesterolaemic animals). The hypolipidaemic effect of VULM 1457 is also observed in the liver of DM-HCH rats (3.9±0.2 mg/g vs. 7.4±1.0 mg/g)[2]. | Animal Model: | Male Wistar rats (250-300 g body weight), fed a standard diet and tap water ad libitum[2] | | Dosage: | 50 mg/kg/day | | Administration: | Administered as an admixture to the fat-cholesterol diet for 5 days | | Result: | Improved the overall myocardial ischaemia-reperfusion injury outcomes in the diabetic-hypercholesterolaemic rats by suppressing arrhythmogenesis as well as by reducing myocardial necrosis, aside from remarkable hypolipidaemic activity. |
| [IC 50]
ACAT |
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