| Identification | Back Directory | [Name]
CAY10568 | [CAS]
22913-17-3 | [Synonyms]
CAY10568
CAY10568,CAY-10568
(2-anilino-2-oxoethyl)-trimethylazanium:iodide
TRIMETHYL ((PHENYLCARBAMOYL)METHYL) AMMONIUM IODIDE | [MDL Number]
MFCD01669691 | [MOL File]
22913-17-3.mol |
| Hazard Information | Back Directory | [Description]
Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported.1 CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact. | [References]
1. Binshtok, A.M., Bean, B.P., and Woolf, C.J. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers Nature 449,607-610(2007). |
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