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229961-45-9

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229961-45-9 Structure

229961-45-9 Structure
IdentificationBack Directory
[Name]

AGN 194310
[CAS]

229961-45-9
[Synonyms]

AGN
CS-1211
VTP194310
VTP-194310
AGN 194310
VTP 194310
AGN-194310, 194310
AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310
Benzoic acid, 4-[2-[4-(4-ethylphenyl)-2,2-dimethyl-2H-1-benzothiopyran-6-yl]ethynyl]-
[Molecular Formula]

C28H24O2S
[MOL File]

229961-45-9.mol
[Molecular Weight]

424.55
Chemical PropertiesBack Directory
[Boiling point ]

598.1±50.0 °C(Predicted)
[density ]

1.26±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

>16.8mg/mL in DMSO
[form ]

Powder
[pka]

4.02±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

AGN 194310 (VTP-194310) is a high-affinity, potent, and selective pan-antagonist of retinoic acid receptors (RARs) with Kd values of 3 nM and 2 nM for RARα, RARβ, and RARγ, respectively , 5 nM.
[in vivo]

AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte -progenitor cells are observed in the bone marrow of mice after treatment with AGN194310.

Animal Model: Female C57Bl/6J mice (Five -week-old (34-37 days))
Dosage: 0.5 mg/kg/ day
Administration: Oral gavage; every day; for 10 days
Result: The number of granulocytes was significantly increased across haemopoietic compartments. Progenitor cells containing granulocytes also increased significantly.
[target]

< /table>

RARα

3 nM (Kd)

RARβ

2 nM (Kd)

RARγ

5 nM (Kd)

[storage]

Store at -20°C
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