| Identification | Back Directory | [Name]
RIPK1-IN-7 | [CAS]
2300982-44-7 | [Synonyms]
RIPK1-IN-7
RIPK1 inhibitor 7
Ethanone, 1-[5-(4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethoxy)phenyl]- | [Molecular Formula]
C25H22F3N5O2 | [MOL File]
2300982-44-7.mol | [Molecular Weight]
481.47 |
| Chemical Properties | Back Directory | [Boiling point ]
724.8±60.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 62.5 mg/mL (129.81 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
5.76±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
RIPK1-IN-7 is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an IC50 of 11 nM. RIPK1-IN-7 has good anti-metastatic activity in an experimental B16 melanoma lung metastasis model. | [in vitro]
RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC 50 of 2nM.
It displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC 50 s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively. | [target]
IC50: 11 nM (RIPK1)
Kd: 4 nM (RIPK1) |
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| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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