| Chemical Properties | Back Directory | [Boiling point ]
838.4±75.0 °C(Predicted) | [density ]
1.56±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.47±0.20(Predicted) | [color ]
Orange to reddish brown |
| Hazard Information | Back Directory | [Description]
F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape. |
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