| Identification | Back Directory | [Name]
5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine | [CAS]
2305415-75-0 | [Synonyms]
5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine | [Molecular Formula]
C10H11N5O5 | [MOL File]
2305415-75-0.mol | [Molecular Weight]
281.23 |
| Hazard Information | Back Directory | [Uses]
5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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