| Chemical Properties | Back Directory | [Boiling point ]
683.5±55.0 °C(Predicted) | [density ]
1.305±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble; Methanol: slightly soluble | [form ]
A crystalline solid | [pka]
13.41±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF-?B activity in RAW-Blue? cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM. | [storage]
Store at -20°C | [References]
1. Guo, H., Verhoek, I.C., Prins, G.G.H., et al. Novel 15-lipoxygenase-1 inhibitor protects macrophages from lipopolysaccharide-induced cytotoxicity J. Med. Chem. 62(9),4624-4637(2019). |
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