ChemicalBook--->CAS DataBase List--->2353409-69-3

2353409-69-3

2353409-69-3 Structure

2353409-69-3 Structure
IdentificationBack Directory
[Name]

Mal-PEG8-Val-Cit-PAB-MMAE
[CAS]

2353409-69-3
[Synonyms]

Mal-PEG8-Val-Cit-PAB-MMAE
[Molecular Formula]

C81H131N11O23
[MDL Number]

MFCD32669864
[Molecular Weight]

1626.97
Chemical PropertiesBack Directory
[Boiling point ]

1438.4±65.0 °C(Predicted)
[density ]

1.191±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

13.29±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

Mal-PEG8-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a maleimide PEG8 moiety, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Mal is reactive with thiol group of antibody.
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