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TCO-PEG4-amine is a bifunctional click chemistry reagent consisting of a TCO and an amine group (NH2). Amine is very reactive with active NHS ester or with carboxylic acid in the presence of of activators suh as EDC. TCO moiety enable fast 3rd generation click chemistry with tetrazine molecule. The inverse-electron demand Diels-Alder cycloaddition of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. |
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