| Identification | Back Directory | [Name]
1-formylisoquinoline thiosemicarbazone | [CAS]
2365-26-6 | [Synonyms]
IQ-1
1-formylisoquinoline thiosemicarbazone
1-Isoquinolinecarbaldehyde thiosemicarbazone
Hydrazinecarbothioamide, 2-(1-isoquinolinylmethylene)- | [Molecular Formula]
C11H10N4S | [MDL Number]
MFCD01717568 | [MOL File]
2365-26-6.mol | [Molecular Weight]
230.29 |
| Hazard Information | Back Directory | [Uses]
IQ 1 disrupts Wnt signaling. IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription. |
|
|