| Identification | Back Directory | [Name]
Azide-PEG4-Tos | [CAS]
236754-49-7 | [Synonyms]
N3-PEG5-Tos
236754-49-7
Azide-PEG4-Tos
Azide-PEG5-Tos
Azido-PEG5-Tos
Azido-PEG5-OTs
N3-PEG5-TOS AZIDE-PEG5-TOS | [Molecular Formula]
C17H27N3O7S | [MDL Number]
MFCD22683295 | [MOL File]
236754-49-7.mol | [Molecular Weight]
417.48 |
| Hazard Information | Back Directory | [Description]
Azide-PEG5-Tos is a crosslinking reagent with two functional groups. PEG spacer increases solubility in aqueous media. The azide(N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic substitution reactions. | [Biological Activity]
Azide-PEG5-Tos (Azido-PEG5-OTs) is a cleavable 5-unit PEG ADC linker for the synthesis of antibody-drug conjugates (ADCs). | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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