| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- | [CAS]
2367619-63-2 | [Synonyms]
TMX-4100
2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- | [Molecular Formula]
C11H10N4O2S | [MOL File]
2367619-63-2.mol | [Molecular Weight]
262.29 |
| Hazard Information | Back Directory | [Biological Activity]
TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma[1].
TMX-4100 (compound 3; 1 μM; 4 h) shows a high degradation preference for PDE6D in MOLT4 cells[1].TMX-4100 has better proteome-wide degradation selectivity in MOLT4 cells, compare to PDE6D degrader FPFT-2216[1].TMX-4100 does not impede the growth of KRAS-dependent cell lines (MIA PaCa-2, NCI-H358, AGS, PA-TU-8988T cells)[1]. | [References]
[1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756. |
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