| Identification | Back Directory | [Name]
Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-2-phenyl-6H-benzocyclohepten-6-ylidene)-, (2E)- | [CAS]
2368927-41-5 | [Synonyms]
Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-2-phenyl-6H-benzocyclohepten-6-ylidene)-, (2E)- | [Molecular Formula]
C19H18O3 | [MOL File]
2368927-41-5.mol | [Molecular Weight]
294.34 |
| Hazard Information | Back Directory | [Description]
Ph-HTBA a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain. Ph-HTBA showed enhanced mid-nanomolar affinity for the CaMKIIα binding site and a marked hub thermalstabilization effect along with a distinct CaMKIIα Trp403 flip upon binding. Moreover, Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice, signified by a high Kp, uu value (0.85). Ph-HTBA is a promising candidate for CaMKIIα-associated pharmacological interventions and future clinical development. |
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