| Identification | Back Directory | [Name]
Propanoic acid, 3-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]ethoxy]ethoxy]ethoxy]- | [CAS]
2375283-62-6 | [Synonyms]
3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid
Propanoic acid, 3-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C22H27N3O9 | [MOL File]
2375283-62-6.mol | [Molecular Weight]
477.46 |
| Chemical Properties | Back Directory | [Boiling point ]
757.8±60.0 °C(Predicted) | [density ]
1.417±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 125 mg/mL (261.80 mM; Need ultrasonic) | [form ]
Solid | [pka]
4.28±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Biological Activity]
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. | [References]
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1002. |
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