ChemicalBook--->CAS DataBase List--->2377881-92-8

2377881-92-8

2377881-92-8 Structure

2377881-92-8 Structure
IdentificationBack Directory
[Name]

Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo-
[CAS]

2377881-92-8
[Synonyms]

MSA-2 dimer
Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo-
[Molecular Formula]

C29H28O8S2
[MOL File]

2377881-92-8.mol
[Molecular Weight]

568.66
Chemical PropertiesBack Directory
[Boiling point ]

817.6±65.0 °C(Predicted)
[density ]

1.376±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

4.10±0.17(Predicted)
[color ]

White to yellow
Hazard InformationBack Directory
[Biological Activity]

MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide[1]. MSA-2 dimer (60 mg/kg; p.o.; 50 days) inhibits tumor growth and prolongs overall survival[1]. MSA-2 dimer (40 mg/kg; s.c.; 25 days) induces complete tumor regression[1].MSA-2 dimer (60 mg/kg; p.o.; 4 hours) increases proinflammatory cytokine (IFN-β) level in tumors[1].MSA-2 dimer (60 mg/kg; s.c.; 4 hours) concentrations is observed in tumors than in plasma or other nontumor tissues [1].MSA-2 dimer (THP-1 cells) induces phosphorylation of both TBK1 and IR. MSA-2 dimer (10 μM and 33 μM; macrophages) induces IFN-β[1].MSA-2 dimer also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes[1].
[References]

[1]. Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369(6506):eaba6098.
2377881-92-8 suppliers list
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: Shanghai?Medlife?Pharm-Tech?Co.,?Ltd  
Tel: 021-59167510 18117107507
Website: www.med-life.cn/
Tags:2377881-92-8 Related Product Information