ChemicalBook--->CAS DataBase List--->2378640-92-5

2378640-92-5

2378640-92-5 Structure

2378640-92-5 Structure
IdentificationBack Directory
[Name]

ENPP1 Inhibitor C
[CAS]

2378640-92-5
[Synonyms]

ENPP1 Inhibitor C
[Molecular Formula]

C15H18N6
[MOL File]

2378640-92-5.mol
[Molecular Weight]

282.34
Chemical PropertiesBack Directory
[density ]

1.29±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
[form ]

A crystalline solid
[pka]

4.27±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

ENPP1 inhibitor C is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50 = 0.26 μM in a cell-free assay).1 It is selective for ENPP1 over ENPP2-7 at 10 μM. ENPP1 inhibitor C decreases ENPP1 activity in MDA-MB-231 human breast and C6 rat glioma cancer cells when used at a concentration of 10 μM.
[storage]

Store at -20°C
[References]

1. Kawaguchi, M., Han, X., Hisada, T., et al. Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging, and prognostic assessment of malignant breast cancer J. Med. Chem. 62(20),9254-9269(2019).
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