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2387505-59-9

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2387505-59-9 Structure

2387505-59-9 Structure
IdentificationBack Directory
[Name]

AP 14145 hydrochloride
[CAS]

2387505-59-9
[Synonyms]

AP 14145 hydrochloride
[Molecular Formula]

C18H18ClF3N4O
[MOL File]

2387505-59-9.mol
[Molecular Weight]

398.81
Chemical PropertiesBack Directory
[solubility ]

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Hazard InformationBack Directory
[Biological Activity]

AP 14145 hydrochloride is a KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM). Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.
[storage]

Store at -20°C
2387505-59-9 suppliers list
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774
Website: www.glpbio.cn
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840 15801484223;
Website: http://www.jm-bio.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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