| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2409538-69-6 | [Synonyms]
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 | [Molecular Formula]
C31H47N5O7S | [MDL Number]
MFCD32173027 | [MOL File]
2409538-69-6.mol | [Molecular Weight]
633.81 |
| Chemical Properties | Back Directory | [Boiling point ]
875.7±65.0 °C(Predicted) | [density ]
1.224±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.54±0.46(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Biological Activity]
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 and PROTAC BRD4 Degrader-5-CO-PEG3-N3 [1].
PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker[1]. | [References]
[1]. Mar? A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312. |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
www.biorbyt.com |
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