| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)- | [CAS]
2414418-49-6 | [Synonyms]
1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)- | [Molecular Formula]
C42H45N11O6 | [MOL File]
2414418-49-6.mol | [Molecular Weight]
799.88 |
| Chemical Properties | Back Directory | [density ]
1.409±0.06 g/cm3(Predicted) | [solubility ]
DMSO:39.99(Max Conc. mg/mL);50.0(Max Conc. mM) | [form ]
Solid | [pka]
10.75±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC?) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide. ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cells in vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines. | [storage]
Store at -20°C |
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