| Identification | Back Directory | [Name]
CLOXAZOLAM | [CAS]
24166-13-0 | [Synonyms]
cs370
Enadel
CS 370
Betavel
Sepazon
Lubalix
Olcadil
Sepazone
Tolestan
mt14-411
MT 14-411
CLOXAZOLAM
Cloxazolazepam
11b-tetrahydro-
oxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one,10-chloro-11b-(o-chlorophenyl)-2,3,
10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
10-chloro-11b-(2-chlorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
10-Chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-oxazolo[3,2-d] [1,4]benzodiazepin-6(5H)-one
Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-
Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one, 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-
10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro- (8CI) | [Molecular Formula]
C17H14Cl2N2O2 | [MDL Number]
MFCD00868152 | [MOL File]
24166-13-0.mol | [Molecular Weight]
349.21 |
| Chemical Properties | Back Directory | [Melting point ]
202-204° (dec) | [Boiling point ]
172°C (rough estimate) | [density ]
1.4125 (rough estimate) | [refractive index ]
1.6100 (estimate) | [pka]
12.70±0.40(Predicted) | [CAS DataBase Reference]
24166-13-0 |
| Hazard Information | Back Directory | [Uses]
A benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675).
Controlled Subs
tance. | [Originator]
Sepazon,Sankyo,Japan,1974 | [Definition]
ChEBI: Cloxazolam is an oxazolobenzodiazepine and a hemiaminal ether. | [Manufacturing Process]
As described in US Patent 3,772,371: To a solution of 5.8 g of 5-chloro-2-
bromoacetylamino-o-chlorobenzophenone in 120 ml of ethanol were added
0.95 g of ethanolamine and 1.3 g of sodium acetate. The resulting mixture
was heated under reflux for 16 hours.
After completion of the reaction, the solvent was distilled off and the residue
was extracted with dichloromethane. The extract was washed with water,
dried over anhydrous sodium sulfate and the solvent was distilled off to give
3.25 g of the desired product melting at 202° to 204°C with decomposition. | [Therapeutic Function]
Tranquilizer |
| Safety Data | Back Directory | [RIDADR ]
3249 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Toxicity]
LD50 in mice (g/kg): 3.3 orally; >2.0 i.p. (Kamioka) |
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