| Identification | Back Directory | [Name]
Urs-12-en-28-amide, 3-hydroxy-N-[2-[(2-hydroxyethyl)methylamino]-2-oxoethyl]-, (3β)- | [CAS]
2416910-69-3 | [Synonyms]
SENP1-IN-1
Urs-12-en-28-amide, 3-hydroxy-N-[2-[(2-hydroxyethyl)methylamino]-2-oxoethyl]-, (3β)- | [Molecular Formula]
C35H58N2O4 | [MOL File]
2416910-69-3.mol | [Molecular Weight]
570.86 |
| Chemical Properties | Back Directory | [Boiling point ]
705.8±60.0 °C(Predicted) | [density ]
1.12±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
14.41±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
SENP1-IN-1 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 29. SENP1-IN-1 is developed for tumor radiosensitivity enhancement[1].
SENP1-IN-1 may improve the sensitivity of tumor cells to irradiation[1].SENP1-IN-1 (0.7-20 μM; 72 hours)has cytotoxic for Hella cells with an IC50 of >20μM[1]. | [References]
[1]. Li, Yiliang, et al. Preparation of ursolic acid derivatives useful as SENP1 inhibitors and tumor radiosensitizer. CN110627860A. |
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