| Identification | Back Directory | [Name]
3,4,5-TRICHLOROTHIOPHENE-2-CARBONYL CHLORIDE | [CAS]
24422-15-9 | [Synonyms]
Rivaroxaban Impurity 166
trichlorothiophene-2-carbonyl chloride
3,4,5-TRICHLOROTHIOPHENE-2-CARBONYL CHLORIDE
3,4,5-trichloro-2-thiophenecarbonyl chloride
2-Thiophenecarbonyl chloride, 3,4,5-trichloro-
3,4,5-Trichlorothien-2-carboxylic acid chloride | [EINECS(EC#)]
-0 | [Molecular Formula]
C5Cl4OS | [MDL Number]
MFCD02093952 | [MOL File]
24422-15-9.mol | [Molecular Weight]
249.93 |
| Hazard Information | Back Directory | [Preparation]
3,4,5-Trichlorothiophene-2-carbonyl chloride synthesis: A mixture of 3,4,5-trichloro-2-thiophenecarboxylic acid (20.4 g, 0.088 mol), SOCl2 (7.3 mL, 0.1 mol), and DMF (0.2 mL) in 80 mL of 1,2-dichloroethane was heated at reflux temperature for 3 h. The reaction mixture became homogeneous after 1 h of heating. The solution was cooled to 25℃, concentrated and placed under high vacuum to remove residual solvent, giving 22.0 g (98% wt.) of 3,4,5-trichloro-2-thiophenecarbonyl chloride as an oil which solidified on standing to an off-white powder; m.p. 37-41℃, having a GC area % purity > 99%. |
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