| Identification | Back Directory | [Name]
PipaMperone Dihydrochloride | [CAS]
2448-68-2 | [Synonyms]
Nsc170981
carpiperone
fluoropipamide
Pipamperone 2HCl
Pipamperone DiHCl
Pipamperone hydrochloride
floropipamide hydrochloride
PIPAMPERONE DIHYDROCHLORIDE
Pipamperone dihydrochloride salt
R4050, 1μ-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4μ-bipiperidine]-4μ-carboxamide dihydrochloride | [EINECS(EC#)]
219-507-5 | [Molecular Formula]
C21H30FN3O2.2ClH | [MDL Number]
MFCD00242980 | [MOL File]
2448-68-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
203-218°C | [storage temp. ]
Hygroscopic, Refrigerator, Under Inert Atmosphere | [solubility ]
H2O: ~50mg/mL | [form ]
powder | [color ]
white | [Water Solubility ]
H2O: >2.0mg/mL | [Stability:]
Hygroscopic |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
1 | [RTECS ]
DW1060000 | [Toxicity]
mouse,LD50,intravenous,71mg/kg (71mg/kg),Drugs in Japan Vol. 6, Pg. 631, 1982. |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Yellow Solid | [Uses]
Antipsychotic. | [Uses]
Pipamperone dihydrochloride may be used:
- as an internal standard in liquid chromatography with coulometric detection
- as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
- as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis
| [Definition]
ChEBI: A hydrochloride resulting from the reaction of pipamperone with 2 mol eq. of hydrogen chloride. It is used as an antipsychotic. | [Biochem/physiol Actions]
Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms. |
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