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2457357-99-0

2457357-99-0 Structure

2457357-99-0 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

2457357-99-0
[Synonyms]

FNC-TP
[Molecular Formula]

C9H14FN6O13P3
[MOL File]

2457357-99-0.mol
[Molecular Weight]

526.16
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

FNC-TP is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1]. FNC (0.1-10 nM; 24-240 h) is found mainly to accumulate in these HIV-1 target cells, and the retention of FNC-TP is 2-4 times higher than in other types of cells[1]. FNC (1-6 mg/kg; a single p.o.) could enter rhesus macaque PBMCs and form the active nucleoside triphosphate FNC-TP[1].
[References]

[1]. Sun L, et, al. Mechanistic Insight into Antiretroviral Potency of 2’-Deoxy-2’-β-fluoro-4’-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J Med Chem. 2020 Aug 13;63(15):8554-8566.
2457357-99-0 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135 , +8613564774135
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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