| Chemical Properties | Back Directory | [Boiling point ]
1240.1±65.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.10±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
SHP2-D26 is a first, potent, and effective PROTAC degrader of SHP2 protein. SHP2-D26 achieves DC50 values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, respectively, and is capable of reducing SHP2 protein levels by >95% in cancer cells. SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines. |
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| Company Name: |
guoyungurui
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| Tel: |
18162595016 |
| Website: |
www.chemicalbook.com/supplier/25521782/ |
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