| Identification | Back Directory | [Name]
L-ASPARAGINE:H2O (2,3,3-D3, 94%) | [CAS]
2483831-59-8 | [Synonyms]
L-ASPARAGINE:H2O (2,3,3-D3, 94%) | [Molecular Formula]
C4H10N2O4 | [MDL Number]
MFCD31814273 | [MOL File]
2483831-59-8.mol | [Molecular Weight]
150.13 |
| Hazard Information | Back Directory | [Biological Activity]
L-Asparagine-d3 is intended for use as an internal standard for the quantification of L-asparagine by GC- or LC-MS. L-Asparagine is a non-essential amino acid.1 It is formed from L-aspartic acid and L-glutamine by asparagine synthetase (ASNS), and it is deamidated by L-asparaginase to produce L-aspartic acid and ammonia.2,3 L-Asparagine (0.3 mM) reverses ASNS siRNA knockdown-induced decreases in proliferation in a panel of six human cancer cell lines, indicating that both exogenous and endogenous L-asparagine promote proliferation of these cells.4 Formulations containing L-asparagine have been used as dietary supplements. | [storage]
-20°C | [References]
1.Chiu, M.I., Taurino, G., Bianchi, M.G., et al.Asparagine synthetase in cancer: Beyond acute lymphoblastic leukemiaFront. Oncol.91480(2020)
2.Zhu, W., Radadiya, A., Bisson, C., et al.High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivityCommun. Biol.2345(2019)
3.Covini, D., Tardito, S., Bussolati, O., et al.Expanding targets for a metabolic therapy of cancer: L-AsparaginaseRecent Pat. Anticancer Drug Discov.7(1)4-13(2012)
4.Pathria, G., Lee, J.S., Hasnis, E., et al.Translational reprogramming marks adaptation to asparagine restriction in cancerNat. Cell Biol.21(12)1590-1603(2019)
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