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ChemicalBook--->CAS DataBase List--->248582-03-8

248582-03-8

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248582-03-8 Structure

248582-03-8 Structure
IdentificationBack Directory
[CAS]

248582-03-8
[Molecular Formula]

C10H22O5S
[Molecular Weight]

254.34
Hazard InformationBack Directory
[Biological Activity]

Thiol-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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