| Chemical Properties | Back Directory | [Boiling point ]
971.7±65.0 °C(Predicted) | [density ]
1.041±0.06 g/cm3(Predicted) | [solubility ]
Ethanol: Soluble | [form ]
Liquid | [pka]
8.88±0.19(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
BAMEA-O16B is a disulfide bond-containing ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro and in vivo. LNPs containing BAMEA-O16B encapsulating Cas9 mRNA and sgRNAs targeting the gene encoding proprotein convertase subtilisin kexin type 9 (PCSK9) accumulate in the liver and decrease serum PCSK9 levels in mice. | [References]
1. Liu, J., Chang, J., Jiang, Y., et al. Fast and efficient CRISPR/Cas9 genome editing in vivo enabled by bioreducible lipid and messenger RNA nanoparticles Adv. Mater. 31(33),e1902575(2019). |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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