Identification | Back Directory | [Name]
1-Naphthalenecarboxamide, N-[2-[[4-(hydroxyamino)-4-oxobutyl]methylamino]ethyl]- | [CAS]
2490709-68-5 | [Synonyms]
DKFZ-748 1-Naphthalenecarboxamide, N-[2-[[4-(hydroxyamino)-4-oxobutyl]methylamino]ethyl]- | [Molecular Formula]
C18H23N3O3 | [MOL File]
2490709-68-5.mol | [Molecular Weight]
329.39 |
Hazard Information | Back Directory | [Uses]
DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66), and shows anti-tumor activity[1]. | [References]
[1] Steimbach RR, et al. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J Am Chem Soc. 2022 Oct 19;144(41):18861-18875. DOI:10.1021/jacs.2c05030 |
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