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2490709-68-5

2490709-68-5 Structure

2490709-68-5 Structure
IdentificationBack Directory
[Name]

1-Naphthalenecarboxamide, N-[2-[[4-(hydroxyamino)-4-oxobutyl]methylamino]ethyl]-
[CAS]

2490709-68-5
[Synonyms]

DKFZ-748
1-Naphthalenecarboxamide, N-[2-[[4-(hydroxyamino)-4-oxobutyl]methylamino]ethyl]-
[Molecular Formula]

C18H23N3O3
[MOL File]

2490709-68-5.mol
[Molecular Weight]

329.39
Chemical PropertiesBack Directory
[density ]

1.203±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

9.49±0.20(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66), and shows anti-tumor activity[1].
[References]

[1] Steimbach RR, et al. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J Am Chem Soc. 2022 Oct 19;144(41):18861-18875. DOI:10.1021/jacs.2c05030
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