| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2512228-06-5 | [Synonyms]
2,5-Dioxopyrrolidin-1-yl 3-(2-(prop-2-yn-1-yloxy)ethoxy)propanoate | [Molecular Formula]
C12H15NO6 | [MDL Number]
MFCD29041934 | [MOL File]
2512228-06-5.mol | [Molecular Weight]
269.25 |
| Hazard Information | Back Directory | [Biological Activity]
Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014. |
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