| Identification | Back Directory | [Name]
4,7,10,13,16-Pentaoxaheptadecanoic acid, 17-phenyl- | [CAS]
2514948-41-3 | [Synonyms]
BnO-(CH2CH2O)4-CH2CH2COOH
4,7,10,13,16-Pentaoxaheptadecanoic acid, 17-phenyl-
1-Phenyl-2,5,8,11,14-pentaoxaheptadecan-17-oic acid | [Molecular Formula]
C18H28O7 | [MDL Number]
MFCD11041123 | [MOL File]
2514948-41-3.mol | [Molecular Weight]
356.41 |
| Hazard Information | Back Directory | [Biological Activity]
Benzyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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