| Identification | Back Directory | [Name]
piperylone | [CAS]
2531-04-6 | [Synonyms]
PR66
piperylone
Piperylonum
4-ethyl-2-(1-methyl-4-piperidyl)-5-phenyl-1H-pyrazol-3-one
4-ethyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one
4-Ethyl-1,2-dihydro-2-(1-methylpiperidin-4-yl)-5-phenyl-3H-pyrazol-3-one
3H-Pyrazol-3-one, 4-ethyl-1,2-dihydro-2-(1-methyl-4-piperidinyl)-5-phenyl- | [EINECS(EC#)]
219-788-4 | [Molecular Formula]
C17H23N3O | [MDL Number]
MFCD00864294 | [MOL File]
2531-04-6.mol | [Molecular Weight]
285.38 |
| Chemical Properties | Back Directory | [Boiling point ]
413.0±55.0 °C(Predicted) | [density ]
1.121±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
pK1 5.90; pK2 9.15(at 25℃) |
| Hazard Information | Back Directory | [Originator]
Palerol, Novartis | [Manufacturing Process]
A mixture of 8.8 parts of α-ethylbenzoylacetic acid ethyl ester and 5,3 parts of N-methyl-piperidyl-4-hydrazine is allowed to stand for 30 min at 22°C, after which the mixture is heated for 5 hours to 130°C under a pressure of 12 mm. After 4 hours 1-(N-methylpiperidyl-4)-3-phenyl-4-ethylpyrazolone-5 begins crystallize out. The reaction mixture is allowed to cool, after which the crystal mass is triturated with ether and then recrystallized from methanol-ether or from acetone. Melting point 159-161°C. | [Therapeutic Function]
Analgesic |
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