| Identification | Back Directory | [Name]
Viniferin | [CAS]
253435-07-3 | [Synonyms]
rel-5-[(2R,3R)-2,3-Dihydro-6-hydroxy-2-(4-hydroxyphenyl)-4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-3-benzofuranyl]-1,3-benzenediol
1,3-Benzenediol, 5-[(2R,3R)-2,3-dihydro-6-hydroxy-2-(4-hydroxyphenyl)-4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-3-benzofuranyl]-, rel- | [Molecular Formula]
C28H22O6 | [MOL File]
253435-07-3.mol | [Molecular Weight]
454.47 |
| Hazard Information | Back Directory | [Description]
α-Viniferin has anti-oxidant and anticancer activities.
?-Viniferin and vincristine can enhance the anti-tumor effects efficiently by inducing HepG2 cell apoptosis.
3. α-Viniferin strongly inhibits the activities of the two CYPs dose dependently.
4. α-Viniferin suppresses the expression of proinflammatory genes iNOS and COX-2 in the early stage of inflammation by inhibiting the Akt/PI3K-dependent NF-κB activation
and inhibits the production of proinflammatory mediators NO and PGE2 in the late stage by stimulating Nrf2-mediated HO-1 signaling pathway in LPS-stimulated BV2 microglial cells. | [target]
NO | PGE | NOS | COX | NF-kB | PI3K | Akt | Nrf2 | HO-1 | P450 (e.g. CYP17) |
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