| Identification | Back Directory | [Name]
20-HETE-D6 | [CAS]
2548939-89-3 | [Synonyms]
20-HETE-D6
20-HYDROXY-5Z,8Z,11Z,14Z-EICOSATETRAENOIC-16,16,17,17,18,18-D6 ACID | [Molecular Formula]
C20H32O3 | [MDL Number]
MFCD05863966 | [MOL File]
2548939-89-3.mol | [Molecular Weight]
320.47 |
| Chemical Properties | Back Directory | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 500 μg/ml | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
20-HETE-d6 contains six deuterium atoms at the 16, 16', 17, 17', 18 and 18' positions. It is intended for use as an internal standard for the quantification of 20-HETE by GC- or LC-MS. 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature.1 In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction.2 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.3 | [References]
1. McGiff, J.C., and Quilley, J. 20-HETE and the kidney: Resolution of old problems and new beginnings Am. J. Physiol. 277(3),R607-R623(1999).
2. Gebremedhin, D., Lange, A.R., Lowry, T.F., et al. Production of 20-HETE and its role in autoregulation of cerebral blood flow Circ. Res. 87(1),60-65(2000).
3. Prakash, C., Zhang, J.Y., Falck, J.R., et al. 20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine Biochem. Biophys. Res. Commun. 185(2),728-733(1992). |
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