| Identification | Back Directory | [Name]
4H-Imidazol-4-one, 3-(1H-benzimidazol-7-ylmethyl)-5-[(3,5-difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2-methyl-, (5Z)- | [CAS]
2561482-42-4 | [Synonyms]
(Z)-3-((1H-benzo[d]imidazol-7-yl)methyl)-5-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-3,5-dihydro-4H-imidazol-4-one
4H-Imidazol-4-one, 3-(1H-benzimidazol-7-ylmethyl)-5-[(3,5-difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2-methyl-, (5Z)- | [Molecular Formula]
C19H14F2N4O2 | [MOL File]
2561482-42-4.mol | [Molecular Weight]
368.34 |
| Chemical Properties | Back Directory | [Boiling point ]
599.0±60.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
6.62±0.40(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
Cell-permeable DFHBI derivative th at selectively binds to Broccoli aptamer; used for imaging of RNA in living cells.
BI is a cell-permeable DFHBI benzimidazolo (DFHBI-BI) derivative th at greatly and selectively promotes and stabilizes Broccoli aptamer folding in vitro and cells with enhanced photostability. BI displays little background in vitro and cells (ϕ=0.00048ϵ=42,500 M-1 cm-1)but very high fluorescence activation after binding to Broccoli (ϕ=0.669ϵ=33,600 M-1 cm-1KD = 51 nM). DFHBI-BI shows negligible cellular toxicity and binds Squash with much weaker affinity than Broccoli. Ex/Em: 470/505 nm. |
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Abosyn
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0512-69561983 13914027025 |
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