| Identification | Back Directory | [Name]
BAY-41-8543 | [CAS]
256498-66-5 | [Synonyms]
BAY-41-8543
BAY-41-8543 Exclusive
BAY 41-8543
(BAY 418543)
2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine
2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine
4,6-Pyrimidinediamine, 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-
BAY 418543,vascular,systemic,antiplatelet,vasodilator,soluble,pulmonary,orally,nitric,beds,cardiovascular,BAY 41 8543,Guanylate Cyclase,Inhibitor,sGC,BAY 41-8543,oxide,inhibit | [Molecular Formula]
C21H21FN8O | [MDL Number]
MFCD18382081 | [MOL File]
256498-66-5.mol | [Molecular Weight]
420.44 |
| Chemical Properties | Back Directory | [Boiling point ]
599.7±50.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [solubility ]
DMF: 3 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
5.18±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BAY 41-8543, is a Guanylyl cyclase (sGC) stimulator, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold. BAY 41-8543 reduces pulmonary vascular resistance and protects right ventricular (RV)function. It also inhibits collagen-induced platelet aggregation, and promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. It has also shown Antihypertensive activity. | [Definition]
ChEBI: BAY-41-8543 is a pyrazolopyridine. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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