| Identification | Back Directory | [Name]
N-ME-AIB-OH HCL | [CAS]
2566-34-9 | [Synonyms]
MeAIB
H-MEAIB-OH
N-ME-AIB-OH
H-(ME)MEALA-OH
N-ME-AIB-OH HCL
N-Me-a-Me-Ala-OH
N,2-DIMETHYLALANINE
2,N-DIMETHYLALANINE
N-ME-ALPHA-ME-ALA-OH
N,2-Dimethyl-DL-alanine
2-Methyl-2-(methylamino)
Methylaminoisobutanoic acid
N-METHYL-ALPHA-METHYL-ALANINE
2-(METHYLAMINO)ISOBUTYRIC ACID
A-(METHYLAMINO)ISOBUTYRIC ACID
N-Methyl-a-aminoisobutyric acid
N-ME-ALPHA-AMINOISOBUTYRIC ACID
ALPHA-(METHYLAMINO)ISOBUTYRIC ACID
2-(Methylamino)isobutyric acid,99%
2-(Methylamino)isobutyric Acid
N-METHYL-ALPHA-AMINOISOBUTYRIC ACID
2-(METHYLAMINO)-2-METHYLPROPIONIC ACID
2-(METHYLAMINO)ISOBUTYRIC ACID HYDRATE
N-Methyl-α-methylalanine hydrochloride
2-Methyl-2-(methylamino)propionic acid
N-METHYL-ALPHA-METHYLALANINE HYDROCHLORIDE
N-Methyl-α-aminoisobutyric acid hydrochloride
2-Methyl-2-(MethylaMino)propanoic acid hydrate
N-METHYL-ALPHA-AMINOISOBUTYRIC ACID HYDROCHLORIDE
N-Methyl-α-aminoisobutyric acid hydrochloride≥ 98% (TLC)
2,N-Dimethylalanine, 2-(Methylamino)-2-methylpropionic acid
α-(Methylamino)isobutyric acid,2,N-Dimethylalanine, 2-(Methylamino)-2-methylpropionic acid | [EINECS(EC#)]
219-898-2 | [Molecular Formula]
C5H11NO2 | [MDL Number]
MFCD06795786 | [MOL File]
2566-34-9.mol | [Molecular Weight]
117.15 |
| Chemical Properties | Back Directory | [Appearance]
WHITE CRYSTALLINE POWDER | [Melting point ]
300 °C | [Boiling point ]
192.5±23.0 °C(Predicted) | [density ]
1.2000 (estimate) | [refractive index ]
1.4650 (estimate) | [storage temp. ]
−20°C
| [Water Solubility ]
almost transparency in Water | [form ]
powder to crystal | [pka]
2.17±0.10(Predicted) | [color ]
White to Almost white | [BRN ]
1746984 |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE CRYSTALLINE POWDER | [Uses]
α-(Methylamino)isobutyric acid (MeAIB) has been used:
- as a system A transport system inhibitor to perform inhibition experiments
- as a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slices
- as an N-acetyltransferase (SNAT) inhibitor in Hankμs balanced salt solution (HBSS) to study its influence on the uptake of 14C-cysteine/ radioactive-labeled cysteine
| [Definition]
ChEBI: Alpha-(methylamino)isobutyric acid is a non-proteinogenic alpha-amino acid that is isobutyric acid in which the alpha-hydrogen has been replaced by a methylamino group. It has a role as a human urinary metabolite. It is an alanine derivative, a non-proteinogenic alpha-amino acid and a secondary amino compound. It is functionally related to an isobutyric acid. It is a conjugate acid of a N-methyl-aminoisobutyrate zwitterion. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 60, p. 8120, 1995 DOI: 10.1021/jo00130a002 | [Biological Activity]
α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway. |
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