| Identification | Back Directory | [Name]
m-PEG9-COOH | [CAS]
2576495-35-5 | [Synonyms]
m-PEG9-COOH
4,7,10,13,16,19,22,25,28-Nonaoxanonacosanoic acid
2,5,8,11,14,17,20,23,26-Nonaoxanonacosan-29-oic acid | [Molecular Formula]
C20H40O11 | [MDL Number]
MFCD27977514 | [MOL File]
2576495-35-5.mol | [Molecular Weight]
456.52 |
| Chemical Properties | Back Directory | [Boiling point ]
536.3±50.0 °C(Predicted) | [density ]
1.111±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
m-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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