| Identification | Back Directory | [Name]
SE 175 | [CAS]
258278-64-7 | [Synonyms]
SE 175
SE 175 >=97%
NO PRODRUG, SE 175
JDIVRBDMTYQVOK-UHFFFAOYSA-N
S-(4-NITROOXYMETHYLBENZOYL)METHYLTHIOSALICYLATE
2-[[4-[(NITROOXY)METHYL]BENZOYL]THIO]-BENZOIC ACID, METHYL ESTER
Benzoic acid, 2-[[4-[(nitrooxy)methyl]benzoyl]thio]-, methyl ester | [Molecular Formula]
C16H13NO6S | [MDL Number]
MFCD03412030 | [MOL File]
258278-64-7.mol | [Molecular Weight]
347.34 |
| Chemical Properties | Back Directory | [Boiling point ]
493.8±45.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMF:50.0(Max Conc. mg/mL);143.53(Max Conc. mM)
DMSO:35.0(Max Conc. mg/mL);100.47(Max Conc. mM)
Ethanol:11.0(Max Conc. mg/mL);31.58(Max Conc. mM) | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors in vivo following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In the intact rat, it stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 20 μM, which is intermediate in potency between nitroglycerine and isosorbide dinitrate. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
|