| Identification | Back Directory | [Name]
N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE | [CAS]
261766-23-8 | [Synonyms]
N-4AIA
N-4ACETIA
N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE
N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE
N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide | [Molecular Formula]
C27H24ClN3O4 | [MDL Number]
MFCD02683236 | [MOL File]
261766-23-8.mol | [Molecular Weight]
489.95 |
| Chemical Properties | Back Directory | [Appearance]
Pale Yellow Solid | [Melting point ]
256-257°C | [storage temp. ]
−20°C
| [solubility ]
DMSO: ≥15 mg/mL
| [form ]
crystalline
| [color ]
Pale Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively | [Description]
N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4-AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2. | [Definition]
ChEBI: N-(4-acetamidophenyl)-Indomethacin amide is a N-acylindole. | [References]
[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70. |
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