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26195-62-0

26195-62-0 Structure

26195-62-0 Structure
IdentificationBack Directory
[Name]

N,O-Dimethylcocsoline
[CAS]

26195-62-0
[Synonyms]

Isotrilobin
Isotrilobine
Homotrilobin
Homotrilobine
(+)-Isotrilobine
N,O-Dimethylcocsoline
2H-22,26-Epoxy-1,24:12,15-dietheno-6,10-metheno-16H-pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-9,21-dimethoxy-4,17-dimethyl-, (4aS,16aS)-
[Molecular Formula]

C36H36N2O5
[MOL File]

26195-62-0.mol
[Molecular Weight]

576.69
Chemical PropertiesBack Directory
[Melting point ]

215°
[alpha ]

D +317° (chloroform)
[density ]

1.232±0.06 g/cm3(Predicted)
[pka]

7.46±0.20(Predicted)
Hazard InformationBack Directory
[Description]

This isomeride of the preceding alkaloid also occurs in Cocculus sarmentosus Diels and C. trilobus DC. It crystallizes in stellate clusters of colourless prisms and has [α]19D + 293°. The dihydrochloride also forms prisms, m.p. 310°C and the dimethiodide decomposes at 262°C. The base also contains two methoxyl groups and two methylimino groups and the corresponding methylmethine has m.p. 115°C and is optically inactive.
[References]

Kondo, Tomita.,!. Pharm. Soc., Japan, 47, 39 (1927)
Kondo, Tomita., ibid, 48, 83 (1928)
Kondo, Tomita., ibid, 50,91 (1930)
Faltis., Annalen, 497, 69 (1932)
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