Identification | Back Directory | [Name]
Indoramin | [CAS]
26844-12-2 | [Synonyms]
Wy-21901 Indoramine Indoramin USP/EP/BP N-[1-[2-(1H-Indol-3-yl)ethyl]piperidin-4-yl]benzamide Benzamide, N-[1-[2-(1H-indol-3-yl)ethyl]-4-piperidinyl]- | [EINECS(EC#)]
248-041-5 | [Molecular Formula]
C22H25N3O | [MDL Number]
MFCD00242841 | [MOL File]
26844-12-2.mol | [Molecular Weight]
347.45 |
Chemical Properties | Back Directory | [Melting point ]
208-210° | [Boiling point ]
600.0±45.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.32±0.20(Predicted) | [color ]
Off-white to light yellow |
Hazard Information | Back Directory | [Originator]
Baratol,Wyeth,UK,1981 | [Uses]
Antihypertensive. | [Definition]
ChEBI: Indoramin is a member of tryptamines. | [Manufacturing Process]
4-Benzamido-1-[2-(3-indolyl)ethyl] pyridinium bromide (3.0 g) was dissolved
in 91% ethanol (300 ml) containing triethylamine (0.08 g) and freshly
prepared W7 Raney nickel catalyst (ca 3 g) was added. The mixture was
hydrogenated in an autoclave at 400 psi hydrogen pressure and 50°C for 4
hours. After filtering off the catalyst the filtrate was evaporated in vacuo and
the residue was shaken with a mixture of chloroform and 2N sodium
hydroxide solution. The resulting insoluble material was filtered off and dried
to give 1.61 g of product, MP 203°C to 206°C. Recrystallization from ethanol
gave the title compound as colorless needles (1.34 g), MP 208°C to 210°C. | [Therapeutic Function]
Antihypertensive |
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