| Identification | Back Directory | [Name]
5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-1,3-diphenyl-2-thioxo-N-[3-(trifluoromethoxy)phenyl]- | [CAS]
2699768-78-8 | [Synonyms]
5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-1,3-diphenyl-2-thioxo-N-[3-(trifluoromethoxy)phenyl]- | [Molecular Formula]
C24H16F3N3O4S | [MOL File]
2699768-78-8.mol | [Molecular Weight]
499.46 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml,DMSO: 10 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Biological Activity]
ARN24139 is a topoisomerase II poison (IC50 = 7.3 μM in a topoisomerase II decatenation assay).1 It inhibits proliferation of DU145, HeLa, and A549 cells (IC50s = 4.7, 3.8, and 3.1 μM, respectively). | [storage]
Store at -20°C | [References]
1.Arencibia, J.M., Brindani, N., Franco-Ulloa, S., et al.Design, synthesis, dynamic docking, biochemical characterization, and in vivo pharmacokinetics studies of novel topoisomerase II poisons with promising antiproliferative activityJ. Med. Chem.63(7)3508-3521(2020)
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