| Identification | Back Directory | [Name]
Acetic acid, 2-[2-[4-[(2-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2) | [CAS]
2702511-37-1 | [Synonyms]
Cetirizine Dihydrochloride Impurity C as Dihydrochloride
Cetirizine Dihydrochloride EP Impurity C as Dihydrochloride
Acetic acid, 2-[2-[4-[(2-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2) | [Molecular Formula]
C21H26Cl2N2O3 | [MOL File]
2702511-37-1.mol | [Molecular Weight]
425.35 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, away from moisture | [solubility ]
DMSO : 100 mg/mL (216.54 mM; Need ultrasonic)| | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
Water : 83.33 mg/mL (180.44 mM; Need ultrasonic) | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Cetirizine (C281100) impurity as histamine inhibitor agent. | [Biological Activity]
Cetirizine Impurity C dihydrochloride is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist[1][2]. | [References]
[1]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [2]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9. |
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