| Identification | Back Directory | [Name]
Miltrione | [CAS]
27210-57-7 | [Synonyms]
C13715
Miltiron
NSC 639662
minestrone
Rosmariquinone
Miltrione USP/EP/BP
8,8-DIMETHYL-2-PROPAN-2-YL-6,7-DIHYDRO-5H-PHENANTHRENE-3,4-DIONE
5,6,7,8-Tetrahydro-2-isopropyl-8,8-diMethyl-3,4-phenanthrenedione
2-Isopropyl-5,6,7,8-tetrahydro-8,8-dimethylphenanthrene-3,4-dione
5,6,7,8-Tetrahydro-8,8-dimethyl-2-isopropyl-3,4-phenanthrenedione
5,6,7,8-Tetrahydro-8,8-diMethyl-2-(1-Methylethyl)-3,4-phenanthrenedione
3,4-Phenanthrenedione,5,6,7,8-tetrahydro-8,8-dimethyl-2-(1-methylethyl)- | [Molecular Formula]
C19H22O2 | [MDL Number]
MFCD00238644 | [MOL File]
27210-57-7.mol | [Molecular Weight]
282.38 |
| Chemical Properties | Back Directory | [Melting point ]
98-100℃ (hexane ) | [Boiling point ]
421.6±45.0 °C(Predicted) | [density ]
1.094±0.06 g/cm3 (20 ºC 760 Torr) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [color ]
Red | [LogP]
4.916 (est) |
| Hazard Information | Back Directory | [Uses]
An active component in Salvia miltiorrhiza that has been shown to inhibit the increase in the abundance of the mRNA for the α4 subunit of the GABAA receptor induced by ethanol withdrawal in cultured hippocampal neurons. A potential phytotherapeutic agent in the treatment of alcohol dependence. | [Definition]
ChEBI: Miltirone is an abietane diterpenoid. | [in vivo]
Miltirone (10-60 mg/kg, p.o.; one hour before test) increases the number of punished crossings in the four-plate test in mice[1].
| Animal Model: | Mice[1] | | Dosage: | 10, 30, 60 mg/kg | | Administration: | Oral gavage (p.o.); an hour before test | | Result: | Increased the number of punished crossings of mice in the 'Four-Plate Test'.
Showed some reversal of the effect of diazepam as expected for a partial agonist.
Produced no muscle relaxant effect and did not impair the performance of mice in the Julou-Courvoisier horizontal wire test.
|
| [IC 50]
CES2: 0.04 μM (Ki) |
|
|